Genes and DNA
Lead Author(s): Saylor Academy
Student Price: FREE
In this question pack, explore the basics of Mendelian genetics, rudimentary nucleic acid-based techniques, genetic technology and gene therapies for genetic disorders.
This content is licensed under the Creative Commons Attribution 3.0 Unported License.
If you cross homozygous red and white snapdragons, then all offspring will have pink flowers.
This is a case of incomplete dominance.
This is a case of dominant inheritance.
This is a case of recessive inheritance.
This is a case of Mendelian inheritance.
In a paternity case, the husband claims that based on his blood type, he cannot possibly be the father of his wife’s child. The husband’s blood type is A, the wife’s blood type is AB, and the child has B blood type.
The husband is right; he cannot be the father. The father of the child must have AB or B blood type.
The husband is right; he cannot be the father. The father of the child must have O blood type.
The husband is wrong. He can be the father, if his genotype is AO.
The husband is wrong. He can be the father, if his genotype is AA.
Jane and Joe are planning to have a child. They both have brown eyes and Bb genotype. They also have wavy hair and Ww genotype. What is the probability that their child will have blue eyes and straight hair? Genotype ww is responsible for straight hair.
1 in 16
2 in 16
3 in 16
9 in 16
Jane Doe has heterozygous brown eyes, and she claims that the father of her blue-eyed son is Joe Brown. Joe Brown has homozygous brown eyes. C an Joe Doe be the father of Jane’s blue-eyed son?
Yes, because Jane has Bb genotype and Joe has BB genotype, where B stands for the dominant brown eye and b stands for the recessive blue eye. There is a 50% chance that their children would be blue-eyed and have Bb or BB genotype.
Yes, because Jane has Bb genotype and Joe has BB genotype, where B stands for the dominant brown eye and b stands for the recessive blue eye. All of their children should be blue-eyed and have Bb or BB genotype.
No, because Jane has BB genotype and Joe has Bb genotype, where B stands for the dominant brown eye and b stands for the recessive blue eye. There is a 50% chance that their children would be brown-eyed and have Bb or BB genotype.
No, because Jane has Bb genotype and Joe has BB genotype, where B stands for the dominant brown eye and b stands for the recessive blue eye. All of their children should be brown-eyed and have Bb or BB genotype.
Consider a population where there are only brown-eyed and blue-eyed individuals, and blue eye color is recessive and brown is dominant. No other alleles influence the eye color in this population. Sixteen percent of this population is blue-eyed. What is the frequency of the blue eye color allele in the population?
Differentially expressed transcripts in tissues, cells, and organisms can be identified with the following method.
C onventional PC R
Real-time RT-PC R
Four cycles result in _______ times amplification during PC R.
Metabolite-sensing can be achieved not only with proteins, but with RNA as well. RNA molecules that can modify metabolism in the cell upon binding a metabolite are called _______.
The synthesis of a C. reinhardtii-adapted gfp resulted in the cgfp gene. The cgfp gene is efficiently expressing GFP protein in this alga because _______.
In the cgfp gene, the codon usage is C. reinhardtii-conform.
The cgfp gene is expressing a different GFP protein sequence.
The cgfp gene is expressing a GFP protein with different color.
In the cgfp gene, there are fewer introns.
Transcript levels in different tissues, cells, and organisms can be compared quantitatively with the following method.
C onventional PC R
Real-time RT-PC R
FISH is an in situ hybridization technique that is using _______ probes to detect homologous nucleic acid sequences in tissues and on chromosomes.
Why are model organisms useful in human genome research?
Model organisms have genes similar to human genes.
Model organisms are mainly used to highlight the differences between animals and humans.
Model organisms can attract animal-loving students to genomics.
A focus on the differences contributes to our understanding of genetic inheritance.
Recombinant gametes are produced with _______.
C rossing over of the sister chromatids during meiosis I.
C rossing over of the non-sister chromatids during meiosis I.
C rossing over of the sister chromatids during meiosis II.
C rossing over of the non-sister chromatids during meiosis II.
The expression of an inserted foreign gene can be _______ influenced by the chromosomal site wherein it is inserted.
A typical plant cell tolerates well if it is placed into hypotonic solution. When protoplasts are placed into hypotonic solution, they _______.
Bacillus thuringiensis is the source of Bt toxin inserted into the Bt plants genome, and Bacillus anthracis is the cause of anthrax. These bacteria differ in their _______ .
Chloramphenicol acetyl transferase (GUS) and green fluorescent protein (GFP) are often used as _______ in transgenic plants.
Cre-lox technology is used to generate _______ transgenic organisms.
Culturing cells in vitro requires _______ the isolated cells.
Providing extracellular matrix for
Adding Ti plasmid to the growth medium of
Inducing de-differentiation of
Inducing viral gene transfer of
Human lactoferrin has been introduced into rice to make it able to bind the trace element _______.
Selective breeding has been historically used to produce offspring with desirable traits. This technique requires careful selection of the parents with _______.
Only recessive homozygous
Only homozygous traits
Only dominant genes
A desired combination of recessive and dominant genes
Animal pharming is the use of transgenic animals for the production of protein drugs. Frequently used animals for pharming are goats, cows, and sheep, wherein the expression of transgenic protein is typically directed to the _______.
Chimeras are also called _______, since they have cells with different genomes.
Dolly, the first cloned mamma, was been generated by _______ technique.
Somatic cell nuclear transfer
Germ line nuclear transfer
In vitro fertilization
Dolly’s premature death is linked to _______ telomere regions.
Her shorter than average
Her longer than average
The absence of the
Generating a cognitive deficit database of mouse mutants is a _______ approach, since it involves behavioral phenotype studies of already established mutant strains.
Knock-in, Knock-out, and conditional transgenic lines must all use _______ sequences at both sides of the chromosomal regions to be changed.
Many Drosophila melanogaster mutants have been generated with random ___. It is expected that targeted transgenesis is aided by _______ in fruit fly genomics.
Site specific insertion; neutralization of position effects
Neutralization of position effects; site specific insertion
P element insertion; recombinases and integrases
Recombinases and integrases; P element insertion.
Transgenic mosquitoes expressing an antigen in their saliva _________ Leishmania infection in a murine model.
offer protection against
attenuate insect bites delivering
GloFish is transgenic zebra fish expressing genetic variants of the jellyfish _______.
Blue fluorescent protein
Green fluorescent protein
Red fluorescent protein
Yellow fluorescent protein
_______ can eliminate the risk of children born with diseases due to the combination of genes inherited from their parents.
Preimplantation genetic diagnosis
Postimplantation genetic diagnosis
Prefertilization genetic diagnosis
Adenovirus has been used to introduce the functional gene in the case of several single gene locus defects, but several cases of leukemia have been reported when patients developed the disease due to the _______ of the introduced functional gene.
High copy number
An epigenetic factor is _______.
C hromosomal rearrangement
C hromosomal inversion
Gene therapy protocols are already in use to introduce functional genes into the patient’s own _______ and return the _______ into the patient.
Stem cells; virus transformed cells
Blood cells; virus transformed cells
Stem cells; mutated cells
Blood cells; mutated cells
HIV gene therapy, which is currently in clinical trial phase, is disrupting the HIV binding receptors on T cell using a specific _______.
In prodrug therapy, an enzyme is delivered to _______ cell, and a prodrug that can be activated by this enzyme is delivered to _______ cell. The drug that is released by the enzyme from the prodrug should be cytotoxic.
Every; a tumor
A tumor, a tumor
A tumor, every
Red-green color blindness is an X-linked recessive trait. What is the probability that the son of a man with normal vision and a carrier woman will be red-green color blind?
Sickle cell anemia is a _______ mutation in the globin gene. It is a deadly disease of homozygote individuals, but it offers protection against _______ in heterozygotes.
Point; malaria parasite
Nonsense; malaria parasite
The _______ method delivers nucleic acid into the cell using high speed metal particles, for example _______.
Gene gun, gold
Gene gun, iron
Particle gun, gold
Particle gun, iron
The most common polyploidy is trisomy 21, which is _______ syndrome.
IGF-1 gene therapy and EPO gene therapy could help people with dystrophin deficiency and kidney failure caused by anemia. These gene therapies may also attract athletes and _______.
Lead to gene doping
Initiate intensive wellness activities
C an be easily accepted in sports
Might to be legalized soon
Our genetic makeup is different as well as our response to a variety of drugs. _______ aims to predict a person’s response to drug therapy.
The aim of using nanoparticles for drug delivery is to _______.
Protect against the body’s immune response
Bring another alternative to the market
Follow these particles with body scanning
Determine how fat particles leaves the body
Content on this site is licensed under a Creative Commons Attribution 3.0 Unported License .
Saylor Academy and Saylor.org® are trade names of the Constitution Foundation, a 501(c)(3) organization through which our educational activities are conducted.
Course Designer: Marianna Pintér